Marosvásárhely / Târgu Mureş lies at the junction of three geographical regions (Mezőség / Câmpia Transilvaniei, Maros Valley and Nyárádmente) at about 220 meters above sea level. The city extends onto both banks of the Maros / Mures river, however, the downtown area and the greater part of the districts are located on the left bank. The Somos-high is the city's highest point (465m above sea level, GPS co-ordinates: width N 46° 33,1840'; lenght E 24° 35,9050' ) The city's climate is moderately continental.

The city is surrounded by the following townships: Marosszentgyörgy (Sîngeorgiu), Jedd (Livezeni), Marosszentanna, Marosszentkirály, Koronka (Corunca) and Maroskeresztúr.

Distances between Târgu Mureş / Marosvásárhely and some of the major cities in Romania:

    * Bucharest: by rail 448 km, by road 346 km
    * Brasov / Brassó / Kronstadt: by rail 282 km, by road 171 km
    * Cluj-Napoca / Kolozsvár 127 km by rail, by road 105 km
    * Sibiu / Nagyszeben / Hermannstadt by rail 189 km, by road 124 km