Hannibal, Missouri, first established in 1819, is best known as the birthplace of Samuel Clemens or as he was known by, Mark Twain. This panorama shows a portion of the old downtown section or historic district, near the boyhood home of Mark Twain. There is a Mark Twain Boyhood Home and Museum. The town is also the setting for two of his most famous books, The Adventures of Tom Sawyer and the Adventures of Huckleberry Finn. There are numerous locations that are associated with both Mark Twain and his fictional characters. Hannibal is located on the Mississippi River and the river is only approximately two blocks east of where this photo was taken. Some of the town’s main attractions are the nearby caves, including the Mark Twain Cave and Cameron Cave. Hannibal is located on Interstate 72 which crosses the Mississippi on the Mark Twain Memorial Bridge.